Antituberculous Activity of Cyanacetic Acid Hydrazide

Synthesis and biological activity of novel amino acid-(N'-benzoyl) hydrazide and amino acid-(N'-nicotinoyl) hydrazide derivatives.

The coupling reaction of benzoic acid and nicotinic acid hydrazides with N- protected L-amino acids including valine, leucine, phenylalanine, glutamic acid and tyrosine is reported. The target compounds, N-Boc-amino acid-(N;-benzoyl)- and N- Boc-amino acid-(N;-nicotinoyl) hydrazides 5a-5e and 6a-6e were prepared in very high yields and purity using N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyr...

Isonicotinic Acid Hydrazide

Synthesis and analgesic activity of novel Hydrazide and Hydrazine derivatives

 The uses of non-steroidal anti-inflammatory drugs (NSAIDs) are limited by a variety of side effects. So research on preparing new analgesic agents is important. According to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesized in order to obtain new analgesic compounds. The final compounds 10a-10e and 15a-15d were pre...

Iron enhances the antituberculous activity of pyrazinamide.

BACKGROUND Pyrazinamide is a paradoxical frontline tuberculosis drug characterized by high in vivo sterilizing activity but poor in vitro activity. This separation in pyrazinamide activity reflects differences between the in vivo tissue environment and in vitro culture conditions. The well-known acid pH requirement for pyrazinamide activity was discovered previously based on such reasoning but ...

Effect of Triiodobenzoic Acid and Maleic Hydrazide

ham University (Newcastle Division, King's College) 1957. 25. KORNBERG, H. and KREBS, H. A. Synthesis of cell constituents from C-units by a modified tricarboxylic acid cycle. Nature 179: 988-991. 1957. 26. BRADBEER, J. W. Some carbohydrate and acid conversions in Kalanchoe crenata. Ph.D. Thesis, Durham University (Newcastle Di-ision, King's College) 1954. 27. STILLER, M. Experiments on the rel...